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Owen Farrell, Brad Barritt and Phil Dowson will make their Test debuts in Saturday's RBS 6 Nations clash with Scotland as part of a new look and inexperienced England team.
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Jonny Wilkinson, Steve Thompson and Lewis Moody have retired, while England are without the injured trio of Toby Flood, Courtney Lawes and Manu Tuilagi. England boast four Saracens players in the back division, with David Strettle joining Farrell, Barritt and Hodgson after being preferred to Gloucester's Charlie Sharples.
Botha will pack down with Tom Palmer in the second row and hooker Dylan Hartley will be propped by Alex Corbisiero on the loose head and Dan Cole at tight head.
ï»¿up for Six Nations opener
The England team features 10 changes from the side that beat Scotland in the World Cup last October and nine from the quarter final defeat to France.
Before that, it was 1969 when David Duckham and John Spencer linked up on debut against Ireland in a 19 17 defeat at Lansdowne Road.
"Now is the time to turn all that into a performance against Scotland that we can all be proud of. It is a massive challenge Murrayfield, the first game of the Six Nations but one we are Nike Huarache Womens Ultra
Saracens pair Farrell and Barritt will become England's first uncapped centre pairing since 2002 and only the second since 1969 while Dowson starts at number eight.
at scrum half.
Saracens lock Mouritz Botha will be making his first international start following a debut off the bench last August.
Up front, Robshaw captains from openside flanker, Tom Croft starts at blindside and Dowson, 30, gets his long awaited Test debut.
Ben Foden, one of four Northampton players, continues at full back with Saracens bound Chris Ashton on the right wing and Ben Youngs Huaraches Black And White High Top
"We have been impressed with how the whole group has come together in the last 10 days and we have done a lot of work on and off the field," Lancaster said.
Farrell has been listed at inside centre with Barritt at outside centre, opposite to the way they line up for Saracens although they will interchange positions.
Lancaster's starting line up boasts just 236 Test caps, including Lions appearances, compared to Scotland's 501. The Scottish pack alone has more international experience than England.
The last time England fielded two debutant centres was in 2002, when Geoff Appleford and Ben Johnston played in a 26 18 win against Argentina in Buenos Aires.
Seven of England's starting XV go into the game with 10 caps or fewer, while Chris Robshaw will captain England in only his second Test appearance.
Saracens prop Matt Stevens will cover both sides while Harlequins full Mens Nike Air Huarache back Mike Brown has been rewarded for his form with a place on the bench, his first England selection since 2008.
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Wasps hooker Rob Webber, Leicester lock Geoff Parling, Scarlets number eight Ben Morgan, Northampton scrum half Lee Dickson and Harlequins centre Jordan Turner Hall are all primed to make their debuts from the bench.
Saracens fly half Charlie Hodgson is the most experienced player in the England line up with 36 caps, but he will be making his first Test start in four years.
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