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David Brennan, chief executive, said: "While the further expected losses of market exclusivity make for a challenging 2012 outlook, we remain committed to a long term, focused, R based strategy, and we have announced further steps to drive productivity in all areas to improve returns on our investment in innovation."
Around 2,200 of the jobs will go in its research and development activities. It is understood that between 250 and 350 face the axe from the R department at Alderley Park, some 10 per cent of the site's total workforce of 3,500.
union, said: "These cutting edge R jobs are both well paid and essential for a thriving UK economy. As a nation, we do need to find a viable way to continue to make breakthroughs in bringing to safe use much needed new medicines."
Astra is the UK's second biggest drugs maker, with 61,000 staff globally, of whom 8,000 are based in Britain.
He said: "Clearly the pharmaceutical industry is going through a very challenging time with many patents expiring, which is reducing expenditure on R our first thoughts need to be with the families who are affected and I've already been talking to AstraZeneca who have assured me there will be proper support available to review career options and relocation opportunities.
It axed 12,600 positions between 2007 and 2009 and another 9,000 roles by the end of last year.
The Anglo Swedish company has suffered a number of setbacks in its efforts to secure approval for new blockbuster drugs.
Alan Black, national officer for the GMB Air Huarache Run Premium
There has been no announcement regarding Macclesfield, the group's second largest manufacturing with around 2,600 staff.
Union bosses have warned that job cuts by pharmaceuticals giant AstraZeneca will be a blow to the UK economy and have vowed to minimise compulsory redundancies.
Shares were down three per cent as the company warned that revenues for 2012 are likely to be down by more than 10 per cent while its margins would also be squeezed, leading to lower Nike Huarache Mens Black And White
The latest blow came as the Cheshire based company announced a two per cent fall in revenues to 21.1bn for 2011, while pre tax profits fell four per cent to 8.4bn.
AstraZeneca announced a 10 per cent hike in its full year dividend and plans to return an additional 2.9bn to shareholders in 2012 on top of the 6bn last year.
Macclesfield MP David Rutley it was "very disappointing news" for the affected employees and their families at Alderley Park many of whom live in Macclesfield.
Linda McCulloch, Unite national officer, said of the cuts: "This is a blow to Britain's R base and Unite will be doing everything possible to minimise compulsory redundancies at Alderley Park.
"I've also spoken to Cheshire East council and they will be bringing a very effective redundancy task force in to help Nike Air Huarache Ultra
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ï»¿Unions vow to minimise AstraZeneca redundancies
AstraZeneca, which has sites at Macclesfield and Nike Air Huarache Run Ultra White Alderley Park in Cheshire, said it will axe 7,300 jobs globally by the end of 2014 as it looks to save 1bn.
"If the company can afford a 10 per cent hike in its dividends, then it can afford to retain these roles."
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